Anyone has any experience making grapics for an isometric 2D game ala diablo, blood omen, or planescape?
Can anyone explain how it works?
Thanks

I think Scott Ruggles has extensive experience there. IIRC you put your camera very far away so perspective distortion is minimal but still present.

2.5d?

Sprites and layered backgrounds. I really don't know what it is you wanted to know?

be more specific. I've worked on iso pixel games a plenty.